CHAPTER 19 Other Useful Kinds of Regression 281

PK theory is well-developed and predicts under a set of reasonable assumptions

that the drug concentration (Conc) in the blood following a bolus infusion should

vary with time (Time) according to the equation:

Conc

C e

o

keTime

TABLE 19-2

Blood Drug Concentration versus Time for One Participant

Time after Dosing (In Hours)

Drug Concentration in Blood (μg/dL)

0.25

57.4

0.5

54.0

1

44.8

1.5

52.7

2

43.6

3

40.1

4

27.9

6

20.6

8

15.0

12

10.0

FIGURE 19-6:

The blood

concentration of

an intravenous

drug decreases

over time in one

participant.

© John Wiley & Sons, Inc.